Group 29 Presentation

Introduction

Materials and Methods

Analysis 1

Analysis 2

Analysis 3

Analysis 4

  • Table: B cells had the most significant markers, showing stronger activation changes.

  • B cells: Tonsil B cells are more activated (CD69, CD80), while blood B cells mature gradually (CD11a, CD80).

  • CD4 T cells: Mature from thymus to blood, losing CD10 and gaining CD25 and CD4_MEM-241.

  • CD8 T cells: Move from active thymus cells to mature blood cells with higher CD27 and CD95.

Analysis 5

  • CD4 and CD8 T cells go through parallel stages

  • How do the CD markers differ between CD4 and CD8 T cells for each stage?

    • As expected CD4 and CD8 are significant different for all pairs
    • CD59 is significant for all stages except TEMRA with a higher log(MedQb) for CD8
    • SP1am and Naive have the lowest number of significant CDs → CD4 and CD8 more similar in these stages

Discussion